Inhaled corticosteroids: potency, dose equivalence and therapeutic index
نویسندگان
چکیده
منابع مشابه
Inhaled steroids: new concepts on therapeutic index and dose equivalence
Background – It is well known that for systemically administered drugs, such as corticosteroids, the therapeutic index cannot be improved by increasing their potency, since efficacy and safety are both attributable to circulating drug concentrations, and common receptor interactions. However, the validity of this assumption has not yet been investigated for inhaled corticosteroids, which are us...
متن کاملAbsorption of high-dose inhaled corticosteroids.
The appropriate and safe use of inhaled corticosteroids (ICS) is an important issue in managing asthma, and we read with interest the article by Wales et al (June 1999).1 This is now the seventh report showing increased adrenal suppression with very high doses of fluticasone propionate (FP) compared to budesonide (BUD) in volunteers.2–7 However, normal subjects do not generally receive these do...
متن کاملModerate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma.
BACKGROUND There is uncertainty as to the dose of inhaled corticosteroids (ICS) at which to start concomitant long acting beta agonist (LABA) treatment in patients with asthma not adequately controlled by ICS alone. METHODS A meta-analysis was carried out of randomised, double blind clinical trials that compared the efficacy of adding salmeterol to moderate doses of ICS (fluticasone propionat...
متن کاملAdrenal function and high dose inhaled corticosteroids for asthma.
OBJECTIVE To investigate effects on adrenal function of fluticasone, a recently released inhaled steroid preparation with lower systemic bioavailability than beclomethasone dipropionate. METHODS 34 children on high doses (400-909 micrograms/m2/d) of inhaled beclomethasone dipropionate or budesonide were recruited into a double blind, crossover study investigating the effects on adrenal functi...
متن کاملPurpura and dermal thinning associated with high dose inhaled corticosteroids.
OBJECTIVE To assess the effect of high dose inhaled corticosteroids on skin. DESIGN Cross sectional study of patients receiving treatment for chest diseases. SETTING Outpatient chest clinic in a teaching hospital. PATIENTS 68 Patients divided into four groups of similar age--namely, 15 receiving long term oral prednisolone, 21 receiving high dose inhaled corticosteroids, 15 receiving low ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2015
ISSN: 0306-5251,1365-2125
DOI: 10.1111/bcp.12637